MICROGLIAL AKAP8L: A KEY MEDIATOR IN DIABETES-ASSOCIATED COGNITIVE IMPAIRMENT VIA AUTOPHAGY INHIBITION AND NEUROINFLAMMATION TRIGGERING

Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering

Abstract Background Diabetes-associated cognitive impairment (DACI) poses a significant challenge to the self-management of diabetes, markedly elevating the risk of adverse complications.A burgeoning body of evidence implicates microglia as a central player in the pathogenesis of DACI.Methods We utilized proteomics to identify potential biomarkers

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Analysis of speech: a reflection on health research

In this study, we take speech and writing as discursive construction, indicating the reasons for making it the object of analysis and introducing different instruments to achieve this.We highlight the importance of discourse analysis for the development of health research, since this method enables VITAMIN B6 100MG the interpretation of reality fro

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Integrated metabolomics and network pharmacology to reveal the mechanisms of hydroxysafflor yellow A against acute traumatic brain injury

Traumatic brain injury (TBI) has become a leading cause of mortality, morbidity and disability worldwide.Hydroxysafflor yellow A (HSYA) is effective in treating TBI, but the potential mechanisms require further exploration.We aimed to reveal the mechanisms of HSYA against acute TBI by an integrated strategy combining metabolomics with network pharm

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Phosphorus fractions in soils with distinct mineralogy and their relationship with phosphate buffer capacity indicators in Brazil

Phosphorus (P) is one of the most important elements used in fertilizing soils in tropical regions due to the low efficiency of phosphate fertilization.This work aimed to fractionate ECHINAFOCE FORTE inorganic P (Pi) in tropical soils of different mineralogical compositions and to relate these fractions with their respective phosphate buffer capaci

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